The ultimate tease of all prescription painkillers. This medicine is tylenol (acetaminophen,paracetamol) combined with codeine, which is a naturally occuring opiate and is therefore a narcotic like all other opiates/opioids. Although it is weaker than oxycodone (OC, Percocets) and hydrocodone (Vicodin), it can still give you a really nice opiate buzz if used in higher doeses. This medicine comes in four different strengths: Tylenol 1,2,3, and 4 which all have different amounts of codeine but the same 300mg of tylenol per pill: Acetaminophen/Codeine (mgs) Tylenol 1 = 300 / 8 Tylenol 2 = 300 / 15 Tylenol 3 = 300 / 30 Tylenol 4 = 300 / 60 These are the most common doses and are commonly nicknamed T(number), for example T3's In the UK, Tylenol 1 and 2 come in over-the-counter form as in the US, all of these are prescription. No doubt, these pills are still really nice to have prescribed for a minor injury, but the reason they are a "tease" is because for those (myself) who try to get high off of the codeine basically have to fucking overdose themselves (myself...) on the tylenol before getting the same buzz. Don't get me wrong, you can still get a nice buzz off of only 100-200 mg's, but after very few times, tolerance kicks in fast and you have to take toxic levels of tylenol before you can get a nice opiated buzz. Many people get liver damage all the time and aren't even aware, but after multiple doses, it can get severe and in higher doses, people end up in the hospital or dead. Codeine has a risk for abuse and addiction, which can lead to overdose and death. Codeine may also cause severe, possibly fatal, breathing problems. To lower your risk, your doctor should have you take the smallest dose of codeine that works, and take it for the shortest possible time. See also How to Use section for more information about addiction. The risk for severe breathing problems is higher when you start this medication and after a dose increase, or if you take the wrong dose/strength. Taking this medication with alcohol or other drugs that can cause drowsiness or breathing problems may cause very serious side effects, including death. Also, other medications can affect the removal of codeine from your body, which may affect how codeine works. Doxycycline 50 mg price Prednisone build muscle Cialis does Acetaminophen, 4'-hydroxyacetanilide, a slightly bitter, white, odorless, crystalline powder, is a non-opiate, non-salicylate analgesic and antipyretic. TYLENOL® with Codeine acetaminophen and codeine No. 4 contains powdered cellulose, magnesium stearate, sodium metabisulfite. Medscape - Indication-specific dosing for Tylenol with Codeine, Tylenol #3. Based on the dosage strength selected and pain severity/tolerance, the prescriber. TYLENOL® with Codeine acetaminophen and codeine No. 3 contains powdered cellulose, magnesium stearate, sodium metabisulfite†, pregelatinized starch. Constipation Drowsiness Hypotension Tachycardia or bradycardia Confusion Dizziness False feeling of well being Headache Lightheadedness Malaise Paradoxical CNS stimulation Restlessness Rash Urticaria Anorexia Nausea Vomiting Xerostomia Ureteral spasm Decreased urination Increased LFTs Burning at injection site Weakness Blurred vision Dyspnea Histamine release Contains acetaminophen Hepatotoxicity may occur with acetaminophen doses that exceed 4 g/day; take into account all acetaminophen-containing products that the patient is taking, including PRN doses and OTC products Acetaminophen has been associated with cases of acute liver failure, at times resulting in liver transplantation or death New dosage limit allows no more than 325 mg/dosage unit for prescription medications that contain acetaminophen Healthcare professionals can direct patients to take 1 or 2 tablets, capsules, or other dosage units of a prescription product containing 325 mg of acetaminophen up to 6 times a day (12 dosage units) and still not exceed the maximum daily dose of acetaminophen of 4 g/day Respiratory depression and death reported following tonsillectomy and/or adenoidectomy in patients that appeared to be rapid metabolizers of codeine due to CYP2D6 polymorphism Acetaminophen has been associated with cases of acute liver failure, at times resulting in liver transplantation and death; risk increases in individuals with underlying liver disease, alcohol ingestion, and/or use of more than 1 acetaminophen-containing product (see Black Box Warnings) Acetaminophen: Risk for rare, but serious skin reactions that can be fatal; these reactions include Stevens-Johnson Syndrome (SJS), toxic epidermal necrolysis (TEN), and acute generalized exanthematous pustulosis (AGEP); symptoms may include skin redness, blisters and rash Acetaminophen may cause serious an potentially fatal skin reactions Patients with G6PD deficiency Use caution in repeated administration in patients with anemia or with cardiovascular, pulmonary, or renal disease Use caution in patients with history of porphyria May cause hypotension; use with caution in patients with hypovolemia Codeine may cause depression; avoid driving car or operating heavy machinery Use caution in patients with conditions associated with hypoxia, hypercapnia, upper respiratory obstruction, or debilitated patients May increase respiratory depressant effects; caution with head injury, COPD, or other conditions associated with decreased respiratory drive Use caution in patients with hypersensitivity reactions to other phenanthrene-derivative opioid agonists including oxymorphone, levorphanol, oxycodone, or hydrocodone Codeine may cause tolerance/dependency May obscure diagnosis or clinical course of patients with acute abdominal conditions and may worsen gastrointestinal ileus due to reduced GI motility Use cuation in adrenal insufficiency, billiary tract impairment, patients susceptible to intracranial effects of CO2 retention, G6PD deficiency, head trauma, prostatic hyperplasia, hepatic/renal impairment, thyroid dysfunction, seizure disorder, or respiratory disease (COPD) Codeine may cause or exacerbate constipation; chronic use may result in obstructive bowel disease, especially in patients with existing intestinal motility disorders; reduce potential for constipation by taking preventive measures, including the increase of fiber intake and the use of stool softeners Long-term use in patients with adrenal insufficiency may cause secondary hypogonadism, which may lead to sexual dysfunction, infertility, mood disorders, and osteoporosis Use with caution in patients with biliary tract dysfunction, including pancreatitis; may increase amylase/lipase levels and may cause constriction of sphincter of Oddi Codeine: Opioid agonist; analgesia; blocks pain impulse generation and inhibits ascending pain pathways, thus altering the perception and response to pain; inhibits cough by acting centrally in the medulla; causes CNS depression Acetaminophen: Nonopioid, nonsalicylate analgesic; may work peripherally to block pain impulse generation; acts on hypothalamus to produce antipyresis The above information is provided for general informational and educational purposes only. Individual plans may vary and formulary information changes. Contact the applicable plan provider for the most current information. This combination product contains three medications: acetaminophen, codeine, and caffeine. Acetaminophen belongs to the group of medications called analgesics (pain relievers) and antipyretics (fever reducers). Codeine belongs to the group of medications called narcotic analgesics. Caffeine belongs to the group of medications called stimulants. This combination of medications is used to treat mild-to-moderate pain associated with conditions such as headache, dental pain, muscle pain, painful menstruation, pain following an accident, and pain following operations. This medication may be available under multiple brand names and/or in several different forms. Any specific brand name of this medication may not be available in all of the forms or approved for all of the conditions discussed here. 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